Inefficient CAR-proximal signaling blunts antigen sensitivity
Venugopal Gudipati, Julian Rydzek, Iago Doel Perez, Vasco Dos Reis Gonçalves, Lydia Scharf, Sebastian Königsberger, Elisabeth Lobner, Renate Kunert, Hermann Einsele, Hannes Stockinger, Michael Hudecek, Johannes B. Huppa
Topics & Concepts
Chimeric antigen receptorAntigenImmunological synapseT-cell receptorCell biologyReceptorMajor histocompatibility complexT cellSignal transductionImmunologyBiologyChemistryImmune systemBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design