The development of thymol–isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity
Atamjit Singh, Kirandeep Kaur, Pallvi Mohana, Karanvir Singh, Aman Sharma, Jignesh Prajapati, Dweipayan Goswami, Neha Khosla, Uttam Kaur, Rajanbir Kaur, Rajinder Kaur, Abhineet Rana, Sandeep Kour, Puja Ohri, Saroj Arora, Renu Chadha, Preet Mohinder Singh Bedi
Abstract
Triazole-tethered isatin-thymol hybrids are developed for targeting multidrug-resistant bacterial strains with efficacy against MRSA acting via CrtM inhibition. The most active hybrid showed bactericidal and antibiofilm efficacy against MRSA and was capable of rescuing larvae from in vivo infection.
Topics & Concepts
MicrobiologyIsatinAntibacterial activityStaphylococcus aureusAntimicrobialDrug resistanceMultiple drug resistanceBiologyChemistryBacteriaGeneticsOrganic chemistryAntimicrobial Peptides and Activitiesvaccines and immunoinformatics approachesRNA Interference and Gene Delivery