Synthesis of Au NPs/<i>Quince</i> nanoparticles mediated by <i>Quince</i> extract for the treatment of human cervical cancer: Introducing a novel chemotherapeutic supplement
Na Li, Guodong Li, Ruina Li, Bikash Karmakar, Attalla F. El‐kott, Mutasem Z. Bani‐Fwaz, Sally Negm, Kareem Morsy
Abstract
In this study, we have prepared mono-dispersed gold nanoparticles using the aqueous extract of Quince . The effective phytocompounds in the extract carried out the function as both reducing and stabilizing agents in the synthesis of Au NPs. The reduction of Au 3+ ions into Au 0 NPs was indicated by a visual transform in color from pale yellow to deep red. UV-Vis studies revealed the characteristic surface plasmon resonance band appeared at around 545 nm. FT-IR, TEM, SEM, EDX, XRD, and UV/Vis analytical methods were employed to characterize the Au NPs/ Quince nanocomposite. TEM study revealed globular shaped NPs having particle size around 20–30 nm. Towards its biological implication, MTT method was followed in order to survey the cytotoxicity and inhibition of human cervical cancer against Hela, SiHa, and CCI-PI 19 cell lines and the corresponding IC 50 values were evaluated as 465, 712, and 785 μ g/mL respectively. The % cell viabilities diminished dose-dependently over the bio-nanomaterial. To survey the antioxidant properties of Au NPs/ Quince , DPPH assay was used and here the related IC 50 value was determined as 72 μ g/mL.