Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1)
Lin Zhao, Bingling Zhong, Yanyan Zhu, Haoyi Zheng, Xumei Wang, Ying Hou, Jin‐Jian Lu, Nana Ai, Xiuli Guo, Wei Ge, Yanyan Ma, Xiuping Chen
Topics & Concepts
Thioredoxin reductaseReactive oxygen speciesApoptosisProgrammed cell deathChemistryCytotoxicityGlutathioneCell growthThioredoxinCancer researchUnfolded protein responseGrowth inhibitionOxidative stressMolecular biologyBiochemistryBiologyEnzymeIn vitroRedox biology and oxidative stressNanoplatforms for cancer theranosticsNeutrophil, Myeloperoxidase and Oxidative Mechanisms