Comprehensive Review on Alzheimer's Disease

Abstract

One of the most prevalent factors contributing to dementia that affects nerve cells is Alzheimer's disease (AD). This neurodegenerative condition is pathologically brought on by extracellular amyloid beta and intracellular neurofibrillary tangles, which lead to the development of plaques that impede communication between the nerve cells. Mutations in the APP, PSEN1, and PSEN2 genes have been discovered to be a hereditary risk factor for this condition. Moreover, diet and nutrition have a significant impact on both the progression and prevention of AD. The biomarker used to identify the disease should be capable of differentiating between dementia's many causes and identifying it at an early stage. Furthermore, using induced pluripotent stem cells has been shown to be a successful method for treating this illness. This chapter's goal is to shed light on the disease's progression and its potential response to stem cell therapy.

Topics & Concepts