<i>In vivo</i>and<i>in vitro</i>studies of antisense oligonucleotides – a review
Anna Kilanowska, Sylwia Studzińska
Abstract
Metabolism of ASOs is based on exonucleases degradation of subsequent nucleotides, with the activity of endonucleases in the case of some modifications.
Topics & Concepts
OligonucleotideIn vivoIn vitroComputational biologyChemistryBiologyGeneticsBiochemistryDNAAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery