Non-alcoholic fatty liver disease – a procoagulant condition?
Lucija Virović-Jukić, Sanja Stojsavljević, Jelena Forgač, Michał Kukla, Ivana Mikolašević
Abstract
Non-alcoholic fatty liver disease (NAFLD) is associated with a number of extrahepatic comorbidities and considerable cardiovascular morbidity and mortality, which is possibly related to coagulation changes associated with metabolic syndrome. Coagulation disorders are common in patients with liver disease of any etiology, and here we review possible alterations in coagulation cascade specific to NAFLD. We discuss derangements in the coagulation cascade and fibrinolysis, endothelial dysfunction, and platelet abnormalities as possible culprits for altered coagulation and explore the significance of these changes for potential treatment targets.
Topics & Concepts
Fatty liverAlcoholic liver diseaseDiseaseMedicineGastroenterologyBiologyInternal medicineCirrhosisLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationPancreatitis Pathology and Treatment