Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression
Feifan Wang, Mengjing Fan, Yueshu Cai, Xuejian Zhou, Shengcheng Tai, Yanlan Yu, Hongshen Wu, Yan Zhang, Jiaxin Liu, Shihan Huang, Ning He, Zhenghui Hu, Xiaodong Jin
Abstract
. Moreover, the circRIMS1/miR-433-3p/CCAR1 regulatory axis was confirmed to be responsible for the biological functions of circRIMS1. Taken together, our research demonstrated that circRIMS1 promotes tumor growth, migration, and invasion through the miR-433-3p/CCAR1 regulatory axis, representing a potential therapeutic target and biomarker in bladder cancer.
Topics & Concepts
microRNABiologyBladder cancerRNACircular RNACancer researchSubclassDownregulation and upregulationCancerIn vivoLong non-coding RNACell growthMolecular biologyApoptosisCell cultureGeneImmunologyGeneticsAntibodyCircular RNAs in diseasesMicroRNA in disease regulationGDF15 and Related Biomarkers