Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes
Huajian Chen, Rui Sun, Tianjiao Zeng, Jing Zheng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Abstract
animal experiments indicated that a strong synergistic effect of PTT and chemotherapy could be achieved at an early stage of treatment before BP degradation, and a mild hyperthermia effect was shown for chemotherapy in the late stage after BP degradation. Moreover, the composite scaffolds after the complete release of Dox could support the proliferation of mesenchymal stem cells. The composite scaffolds showed a synergistic effect of stepwise PTT and chemotherapy for breast cancer elimination and promoted stem cell activities after killing cancer cells.
Topics & Concepts
DoxorubicinPhotothermal therapyIn vivoGelatinChemotherapyChemistryCancer cellPhotothermal effectBiophysicsMaterials scienceBiomedical engineeringCancer researchCancerNanotechnologyBiochemistrySurgeryMedicineInternal medicineBiologyBiotechnologyNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseNanoparticle-Based Drug Delivery