Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration
Li X, Xuenan Wang, Chao Chen, Enyu Zhang, Yuan Zhang, Hongkun Li, Yu Lei, Zhenkai Lou, Fan Zhang
Topics & Concepts
Ubiquitin ligaseCell biologyChemistryTransactivationCoactivatorMatrix metalloproteinaseTranscription factorDownregulation and upregulationUbiquitinRUNX2Molecular biologyCancer researchBiologyBiochemistryGeneSpine and Intervertebral Disc PathologyCervical and Thoracic MyelopathyProtease and Inhibitor Mechanisms