<i>Enterobacter aerogenes</i> ZDY01 inhibits choline-induced atherosclerosis through CDCA-FXR-FGF15 axis
Jinghui Tang, Manman Qin, Le Tang, Dan Shan, Cheng Zhang, Yifeng Zhang, Hua Wei, Liang Qiu, Jun Yu
Abstract
ZDY01 utilized TMA and reduced TMAO level, increased abundance of gut microbiota, accelerated resorption of bile acids into blood by upregulating Asbt and Ostα / β expression, and inactivated FXR-FGF15 axis resulting in increased CYP7A1 expression.
Topics & Concepts
Enterobacter aerogenesCholineChemistryTrimethylamine N-oxideCarnitineMetaboliteCholesterolTrimethylamineMicrobiologyBiochemistryBiologyEscherichia coliGeneGut microbiota and healthPancreatitis Pathology and TreatmentEsophageal and GI Pathology