Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia
Peng Cao, Yuanjue Wu, Sanlan Wu, Tingting Wu, Qilin Zhang, Rui Zhang, Zhao Wang, Yu Zhang
Abstract
AIM: Ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown. METHOD: We collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed. RESULTS: < 0.001). CONCLUSIONS: It suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.
Topics & Concepts
FerritinReceiver operating characteristicMedicineGastroenterologyInternal medicineLiver injuryPneumoniaSeverity of illnessIncidence (geometry)Area under the curveBiomarkerSerum ferritinDiseaseBiologyBiochemistryOpticsPhysicsIron Metabolism and DisordersCOVID-19 Clinical Research StudiesHemoglobinopathies and Related Disorders