Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway
Qianwen Zheng, Qin Li, Gang Zhao, Jie Zhang, Hang Yuan, Di Gong, Yafei Guo, Xinhua Liu, Kai Li, Ping Lin
Topics & Concepts
AutophagyApoptosisp38 mitogen-activated protein kinasesReactive oxygen speciesCell biologyMAPK/ERK pathwayCytotoxicityCancer cellBiologySignal transductionCytotoxic T cellChemistryBiochemistryCancerIn vitroGeneticsAutophagy in Disease and TherapyBioactive Compounds and Antitumor AgentsSynthesis of Indole Derivatives