An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging
Liandi Guan, Wanting Hu, Hongzhi Zuo, Hua Sun, Yongjian Ai, Mengqi He, Cheng Ma, Mingyu Ding, Qionglin Liang
Abstract
A novel probe was synthesized with a turn-on NIR fluorescent (NIRF)/photoacoustic (PA) response to NADPH, which was successfully applied in both monitoring intracellular NADPH and dual-modal imaging of tumor-bearing mice. It exhibits good potential in studying and understanding the tumor energy metabolism and treatment process related to NADPH.
Topics & Concepts
Photoacoustic imaging in biomedicineFluorescenceIntracellularDual modeBiophysicsChemistryMaterials scienceOpticsBiochemistryBiologyAerospace engineeringEngineeringPhysicsPhotoacoustic and Ultrasonic ImagingNanoplatforms for cancer theranosticsAnalytical Chemistry and Sensors