Click-tambjamines as efficient and tunable bioactive anion transporters
Israel Carreira‐Barral, Marcin Mielczarek, Daniel Alonso-Carrillo, Valeria Capurro, Vanessa Soto‐Cerrato, Ricardo Pérez‐Tomás, Emanuela Caci, María García‐Valverde, Roberto Quesada
Abstract
A novel class of transmembrane anion carriers, the click-tambjamines, display remarkable anionophoric activities in model liposomes and living cells. The versatility of this building block for the generation of molecular diversity offers promise to develop future drugs based on this design.
Topics & Concepts
Transmembrane proteinClick chemistryLiposomeBlock (permutation group theory)ChemistryCombinatorial chemistryIonTransporterNanotechnologyBiophysicsComputer scienceMaterials scienceBiochemistryOrganic chemistryBiologyReceptorGeneGeometryMathematicsAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionDNA and Nucleic Acid Chemistry