In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders
Morten Grupe, Bo Hjorth Bentzen, Tau Benned‐Jensen, Vibeke Nielsen, Kristen Frederiksen, Henrik Jensen, Anne‐Marie Jacobsen, Lasse Skibsbye, Anette Sams, Morten Grunnet, Mario Rottländer, Jesper F. Bastlund
Topics & Concepts
EpilepsyIn vivoPharmacologySchizophrenia (object-oriented programming)AnticonvulsantGABAA receptorAntipsychoticNeuroscienceAntidepressantBehavioural despair testMedicineSeizure thresholdPsychologyBiologyInternal medicinePsychiatryReceptorHippocampusBiotechnologyIon channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research