Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy
Jianmin Hu, Yueshuo Li, Hongde Li, Feng Shi, Longlong Xie, Lin Zhao, Min Tang, Xiangjian Luo, Wei‐Hua Jia, Jia Fan, Jian Zhou, Qiang Gao, Shuang–Jian Qiu, Wei‐Zhong Wu, Xin Zhang, Weihua Liao, Ann M. Bode, Ya Cao
Abstract
Oxidative stress mediates EBV reactivation and leads to radioresistance. Targeting oxidative stress can provide therapeutic benefits to cancer patients with radiation resistance. Clinically, we, for the first time, generated a molecular subtyping model for NPC relying on 8-OHdG and EBV DNA level. These dual markers could identify patients who are at a high risk of poor outcomes but who might benefit from the sequential therapy of reactive oxygen blockade followed by radiation therapy, which provides novel perspectives for the precise treatment of NPC.