Evidence for an HPV one-dose schedule
Margaret Stanley, Anne Schuind, Kirthini Muralidharan, Dominique Guillaume, Victoria Willens, Hannah Borda, Marley Jurgensmeyer, Rupali J. Limaye
Abstract
The World Health Organization has recently updated their dosing schedule recommendations for the human papillomavirus (HPV) vaccine to include a single-dose schedule. We review the biologic plausibility of a single dose, the evidence from clinical trials, post-licensure observational studies, and mathematical modeling for a single-dose schedule. We also discuss the implications of countries switching to a single-dose program from a two or three-dose schedule. Finally, we review the countries that have currently switched to or introduced the vaccine with a single-dose schedule.
Topics & Concepts
ScheduleMedicineComputer scienceOperating systemCervical Cancer and HPV ResearchHepatitis B Virus StudiesMolecular Biology Techniques and Applications