Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H<sub>1</sub> Receptor
Zhi Yuan Kok, Leigh A. Stoddart, Sarah J. Mistry, Tamara A. M. Mocking, Henry F. Vischer, Rob Leurs, Stephen J. Hill, Shailesh N. Mistry, Barrie Kellam
Abstract
R predicts that the optimized peptide linker makes interactions with key residues in the receptor.
Topics & Concepts
LinkerChemistryFluorophoreFluorescencePeptideHistamineBiophysicsBODIPYLigand (biochemistry)ReceptorIn vivoG protein-coupled receptorCombinatorial chemistryIn vitroBiochemistryPharmacologyBiologyComputer scienceBiotechnologyOperating systemQuantum mechanicsPhysicsMast cells and histamineReceptor Mechanisms and SignalingChemical Synthesis and Analysis