Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans
Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda, Hiroyuki Kusuhara
Topics & Concepts
JejunumCaco-2In vivoIntestinal epitheliumEnzymeIn vitroTransporterBiologyMolecular biologyCell cultureIntestinal mucosaChemistrySmall intestineEnzyme assayBiochemistryEpitheliumPharmacokineticsEx vivoP-glycoproteinPharmacologyCellAbsorption (acoustics)Internal medicineDrug metabolismIleumEndocrinologyCarboxylesteraseDrugAbcg2Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsBarrier Structure and Function Studies