Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2
Yu Jiang, Lingling Luo, Tong Hu, Yating Cui, Xiao Sun, Wenfeng Gou, Wenbin Hou, Yiliang Li, Tiemin Sun
Topics & Concepts
Poly ADP ribose polymeraseChemistrySelectivityIC50PolymerasePARP inhibitorStereochemistryPharmacologyBiochemistryIn vitroEnzymeBiologyCatalysisPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisPlant Genetic and Mutation Studies