ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression
Hui Shi, Ting Tao, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, Cigall Kadoch, A. Thomas Look
Abstract
is a haploinsufficient tumor suppressor in MYCN-driven neuroblastoma, whose depletion enhances tumor development and promotes the emergence of the more drug-resistant mesenchymal cell state.
Topics & Concepts
NeuroblastomaARID1AEnhancerBiologyChromatinCancer researchChromatin remodelingRegulation of gene expressionCell biologyGeneGene expressionMolecular biologyGeneticsMutationCell cultureChromatin Remodeling and CancerNeuroblastoma Research and TreatmentsProtein Degradation and Inhibitors