Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease
Yuanyuan Shen, Lingchen Hua, Chih‐Kuang Yeh, Liming Shen, Ming Ying, Zaijun Zhang, Gong‐Ping Liu, Shupeng Li, Siping Chen, Xin Chen, Xifei Yang
Abstract
Our findings reinforce the positive therapeutic effects on AD models with both Aβ and tau pathology induced by FUS/MB-mediated BBB opening, further supporting the potential of this treatment regime for clinical applications.
Topics & Concepts
HippocampusHippocampal formationMorris water navigation taskGenetically modified mousePathologyAlzheimer's diseaseNeuroscienceMicrogliaWater mazeMedicineChemistryPsychologyTransgeneDiseaseInternal medicineInflammationBiochemistryGeneUltrasound and Hyperthermia ApplicationsTraumatic Brain Injury and Neurovascular DisturbancesS100 Proteins and Annexins