“Fill States”: PET-derived Markers of the Spatial Extent of Alzheimer Disease Pathology
Elena Doering, Merle C. Hoenig, Kathrin Giehl, Verena Dzialas, Grégory Andrassy, Abdelmajid Bader, Andreas Bauer, David Elmenhorst, Johannes Ermert, Silke Frensch, Elena Jaeger, Frank Jessen, Philipp Krapf, Tina Kroll, Christoph Lerche, Julia Lothmann, Andreas Matusch, Bernd Neumaier, Oezguer A. Onur, Alfredo Ramı́rez, Nils Richter, Frederik Sand, Lutz Tellmann, Hendrik Theis, Philip Zeyen, Thilo van Eimeren, Alexander Drzezga, Gérard N. Bischof, for the Alzheimer's Disease Neuroimaging Initiative
Abstract
The spatial extent of amyloid, tau, and neurodegeneration, derived from PET imaging, has higher diagnostic performance for cognitive impairment severity compared with standardized uptake value ratios.
Topics & Concepts
MedicineNeurodegenerationStandardized uptake valueAlzheimer's diseasePet imagingPathologyAmyloid (mycology)Tau pathologyCognitive impairmentPositron emission tomographyDiseaseNuclear medicineDementia and Cognitive Impairment ResearchMedical Imaging Techniques and ApplicationsFunctional Brain Connectivity Studies