Sugammadex Administration in Pregnant Women: A Case Series of Maternal and Fetal Outcomes
Shubhangi Singh, Thomas T. Klumpner, Carlo Pancaro, Baskar Rajala, Joanna A. Kountanis
Abstract
Sugammadex, given its high affinity for amino-steroid neuromuscular blockers, offers rapid and reliable neuromuscular blockade reversal, making it a popular reversal agent. This characteristic can be very useful in pregnant women, where incomplete reversal can have poor maternal and fetal outcomes. However, its use antenatally in pregnancy is controversial given concerns for progesterone binding, a hormone that is crucial for maintenance of pregnancy. This case series presents obstetric and fetal outcomes in 25 pregnant women who received sugammadex during the antenatal period, thus highlighting the need for further research into the safety of sugammadex during pregnancy.