Cp*Rh<sup>III</sup>-Catalyzed Cascade Annulation of Arylimidates with Pyridotriazoles toward Isoquinolin-3-ol Derivatives
Weidan Yan, Luo Hong, Qiling Wu, Liansheng Liu, Jing Li, Junfa Wei
Abstract
-catalyzed efficient synthesis of isoquinolin-3-ol derivatives bearing a pyridinyl ring using imidate as a directing group under C-H activation strategy with pyridotriazoles as carbene reagents is reported. In this reaction, cascade C-H activation, regioselective cyclization, and elimination occur in one pot. The present methodology featured a good range of functional group tolerance and furnished the target products in moderate-to-excellent yields.
Topics & Concepts
ChemistryAnnulationRegioselectivityCatalysisCarbeneReagentCascadeRing (chemistry)Cascade reactionCombinatorial chemistryMedicinal chemistryFunctional groupReaction conditionsOrganic chemistryChromatographyPolymerCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions