Enhancing the mechanical properties and osteogenic differentiation of Mg-1 wt.%Ho alloy by tailoring microstructures through extrusion temperatures
Xuanxin Chen, Shibo Zhou, Hui Shi, Yulong Wu, Tao Chen, Wenxiang Huang
Abstract
This investigation was conducted to explore the impact of extrusion temperature on the microstructure, mechanical properties, and osteogenic differentiation of the as-extruded Mg-1Ho alloy. The Mg-1Ho alloy was extruded at three different temperatures, i.e., 320, 350, and 380 °C, leading to variation in its grain size and texture intensity. With decreasing extrusion temperature, a significant increase was achieved in its room-temperature ultimate tensile strength (UTS) and yield strength (YS). After being subjected to an extrusion temperature of 320 °C, furthermore, Mg-1Ho alloy can effectively promote osteogenic proliferation and differentiation, anti-inflammatory, along with osteogenic gene expression. Our findings emphasized that adding extract from Mg-1Ho alloy extruded at 320 °C enhanced the ability of osteogenesis, demonstrating its potential as a biomaterial to improve cell performance and fate.