Silybin and its congeners: from traditional medicine to molecular effects
Vladimı́r Křen, Kateřina Valentová
Abstract
Recent developments in chemistry, biosynthesis, analytical methods, and transformations of flavonolignans from silymarin are presented. Their pharmacology, biological activities, SAR and safety with special attention to the chirality are discussed.
Topics & Concepts
Chirality (physics)ChemistryComputational biologyNanotechnologyPharmacologyTraditional medicineStereochemistryBiochemistryMedicineBiologyPhysicsMaterials scienceNambu–Jona-Lasinio modelQuantum mechanicsChiral symmetry breakingQuarkSilymarin and Mushroom PoisoningSynthesis and bioactivity of alkaloidsBerberine and alkaloids research