High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development
Shalev Gihaz, Peter C. Gareiss, Jae‐Yeon Choi, Isaline Renard, Anasuya Pal, Yulia Surovsteva, Joy E. Chiu, Jose Thekkiniath, Mark S. Plummer, William Hungerford, Micaela L. Montgomery, Alanah Hosford, Emily M. Adams, Jorge D. Lightfoot, David Fox, Kayode K. Ojo, Bart L. Staker, Kevin K. Fuller, Choukri Ben Mamoun
Topics & Concepts
Coenzyme ABiologyEnzymeDrug discoveryBiochemistryHigh-throughput screeningAntifungalMode of actionLigand (biochemistry)Mechanism of actionMicrobiologyReceptorIn vitroReductaseNeurological diseases and metabolismRNA and protein synthesis mechanismsMicrobial Natural Products and Biosynthesis