LuxT Is a Global Regulator of Low-Cell-Density Behaviors, Including Type III Secretion, Siderophore Production, and Aerolysin Production, in Vibrio harveyi
Michaela J. Eickhoff, Chenyi Fei, Jian-Ping Cong, Bonnie L. Bassler
Abstract
species, ubiquitous marine bacteria that often cause disease. We characterize the mechanisms by which LuxT controls genes involved in virulence and nutrient acquisition. We show that LuxT functions in parallel with a set of regulators of the bacterial cell-to-cell communication process called quorum sensing to promote V. harveyi behaviors at low cell density.
Topics & Concepts
Vibrio harveyiBiologyRegulatorQuorum sensingAutoinducerVibrioGeneSiderophoreType three secretion systemTranscriptional regulationRepressorRegulator geneGeneticsMicrobiologyRegulation of gene expressionCell biologyGene expressionBacteriaVirulenceVibrio bacteria research studiesBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology