Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery
Élise Rouleau-Turcotte, Dragomir B. Krastev, Stephen J. Pettitt, Christopher J. Lord, John M. Pascal
Topics & Concepts
PARP1Poly ADP ribose polymeraseNAD+ kinaseBiologyAllosteric regulationActive siteBiophysicsBiochemistryDNA damageMolecular mechanicsDNACell biologyEnzymeMolecular dynamicsChemistryPolymeraseComputational chemistryPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisDNA Repair Mechanisms