Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
Annie Y. Yao, Riqiang Yan
Abstract
The activity of γ-secretase is critical to the pathogenesis of Alzheimer's disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.
Topics & Concepts
Innate immune systemTransmembrane proteinInterferonImmunityPathogenesisInflammasomeAmyloid precursor protein secretaseMolecular neuroscienceDiseaseNeuroscienceAmyloid (mycology)Amyloid precursor proteinRegulatorAmyloid βBiologyCell biologyImmunologyAlzheimer's diseaseMedicineInflammationImmune systemReceptorBiochemistryInternal medicinePathologyGeneAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders