Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii
Suchita Rastogi, Yuan Xue, Stephen R. Quake, John C. Boothroyd
Abstract
This work performs transcriptomic analysis of U-I cells, captures the earliest stage of a host cell’s interaction with Toxoplasma gondii , and dissects the effects of individual classes of parasite effectors on host cell biology.
Topics & Concepts
RhoptryBiologyToxoplasma gondiiEffectorIntracellular parasiteDense granuleCell biologyBystander effectPopulationTranscriptomeImmune systemIntracellularImmunologyGene expressionGeneApicomplexaGeneticsAntibodyPlasmodium falciparumSociologyDemographyMalariaToxoplasma gondii Research StudiesCytomegalovirus and herpesvirus researchinterferon and immune responses