Reductive <i>N-</i>Formylation of Nitroarenes Mediated by Rongalite
Huai‐Yu Wang, Xiang‐Long Chen, Chun‐Yan Wu, Dongsheng Yang, Ting Chen, An‐Xin Wu
Abstract
Herein, we disclose a straightforward approach to access transition-metal-free reductive N -formylation of nitroarenes. This reaction integrates the dual role of rongalite, which acts as a reductant and a C1 building block concurrently. This provides an alternative method for the synthesis of N -aryl formamides from nitroarenes, including the construction of a C–N bond. The utility of this protocol was demonstrated by scale-up synthesis and late-stage functionalizations of complex molecules.
Topics & Concepts
FormylationChemistryCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisNanomaterials for catalytic reactionsAsymmetric Hydrogenation and CatalysisChemical Synthesis and Reactions