Surgery for acromegaly: Indications and goals
David P. Bray, Sneha Sai Mannam, Rima S. Rindler, Joseph Quillin, Nelson M. Oyesiku
Abstract
Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when patients do not achieve biochemical cure after surgical therapy.
Topics & Concepts
AcromegalyMedicinePituitary adenomaAdenomaAdverse effectGrowth hormoneGold standard (test)Radiation therapyMedical therapyPituitary tumorsSurgeryInternal medicineHormonePituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsGlioma Diagnosis and Treatment