Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting
Ghadir Kalot, Amélie Godard, Benoît Busser, Mohamed Bendellaa, Fabien Dalonneau, Catherine Paul, Xavier Le Guével, Véronique Josserand, Jean‐Luc Coll, Franck Denat, Ewen Bodio, Christine Goze, Thomas Gautier, Lucie Sancey
Abstract
, in particular with LDL. The tumor uptake mechanism of SWIR-WAZABY-01 was investigated based on the presence of low-density lipoprotein (LDL) receptors and passive tumor uptake. Overall, we found that SWIR-WAZABY-01 interacts with lipoproteins enhancing their NIR-II fluorescence emission, and driving the tumor accumulation with regards to the expression of lipoprotein receptors (LDLR, SR-BI). Moreover, SWIR-WAZABY-01, by exploiting endogenous lipoproteins, arises as a new, potent and relevant tool to efficiently label LDL involved in pathologies.