Inhibition of <i>Toxoplasma gondii</i> by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine
Lidia Węglińska, Adrian Bekier, Nazar Trotsko, Barbara Kaproń, Tomasz Plech, Katarzyna Dzitko, Agata Paneth
Abstract
properties to advance into preclinical development; it showed ability to cross the BBB, did not induce genotoxic and haemolytic changes in human cells, and as well as it was characterised by low cellular toxicity.
Topics & Concepts
SulfadiazinePyrimethamineToxoplasma gondiiPharmacologySelectivityChemistryToxoplasmosisIC50TriazoleDrugCombinatorial chemistryStereochemistryIn vitroBiochemistryPlasmodium falciparumMedicineVirologyAntibioticsImmunologyOrganic chemistryMalariaAntibodyCatalysisToxoplasma gondii Research StudiesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation