Litcius/Paper detail

Transition-Metal-Free Silylation of Unactivated C(sp<sup>2</sup>)–H Bonds with <i>tert</i>-Butyl-Substituted Silyldiazenes

Baptiste Neil, Franck Lucien, Louis Fensterbank, Clément Chauvier

2021ACS Catalysis36 citationsDOI

Abstract

Aromatic organosilanes bearing C(sp2)–Si bonds have found increasing applications across the chemical science, yet are mostly produced by atom-uneconomical stoichiometric procedures. Catalytic alternatives using hydrosilanes as silicon sources have also been described, but they display unfavorable thermodynamics and are mostly based on expensive catalytic systems, often derived from noble metals, or lack generality. Herein, we describe the use of an alternative silicon source, namely the tert-butyl-substituted silyldiazenes (tBu–N═N–SiR3), that are readily accessible from commercially available precursors and whose structure enables the C(sp2)–H bond silylation of unactivated heteroaryl and aryl compounds under ambient, transition-metal-free catalytic conditions.

Topics & Concepts

SilylationCatalysisTransition metalChemistrySiliconArylAtom (system on chip)StoichiometryCombinatorial chemistryOrganic chemistryEmbedded systemComputer scienceAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry