3D Printed Multifunctional Ti <sub>6</sub> Al <sub>4</sub> V-Based Hybrid Scaffold for the Management of Osteosarcoma
Bianyun Cai, Leizhen Huang, Jingcheng Wang, Dan Sun, Ce Zhu, Yong Huang, Shujun Li, Zhijun Guo, Limin Liu, Ganjun Feng, Yubao Li, Li Zhang
Abstract
Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV–vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.