Activation of ERK1/2-mTORC1-NOX4 mediates TGF-β1-induced epithelial-mesenchymal transition and fibrosis in retinal pigment epithelial cells
Soo‐Jin Kim, Yun-Sang Kim, Jeong Hun Kim, Ha Young Jang, Dat Da Ly, Ranjan Das, Kyu‐Sang Park
Topics & Concepts
Epithelial–mesenchymal transitionmTORC1Cell biologyNADPH oxidaseNOX4MAPK/ERK pathwayCancer researchChemistrySignal transductionTransforming growth factorMEK inhibitorp38 mitogen-activated protein kinasesReactive oxygen speciesDownregulation and upregulationBiologyPI3K/AKT/mTOR pathwayBiochemistryGeneRetinal and Macular SurgeryGlaucoma and retinal disordersRetinal Diseases and Treatments