Polygenic architecture of rare coding variation across 394,783 exomes
Daniel J. Weiner, Ajay Nadig, Karthik A. Jagadeesh, Kushal K. Dey, Benjamin M. Neale, Elise Robinson, Konrad J. Karczewski, Luke J. O’Connor
Topics & Concepts
HeritabilityGenetic architectureBiologyMissing heritability problemGeneticsExomeGenome-wide association studyExome sequencingGenetic associationGenetic variationAlleleGeneAllele frequencyLinkage disequilibriumEvolutionary biologyQuantitative trait locusPhenotypeSingle-nucleotide polymorphismHaplotypeGenotypeGenetic Associations and EpidemiologyGenomics and Rare DiseasesBioinformatics and Genomic Networks