Focus on gastroesophageal reflux disease in patients with cystic fibrosis
Annarita Bongiovanni, Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Enza Mulè, Novella Rotolo, Salvatore Leonardi
Abstract
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder in cystic fibrosis (CF), and based on various studies, its prevalence is elevated since childhood. There are several pathogenetic mechanisms on the basis of association between CF and GERD. However, there are no specific guidelines for GERD in CF patients, so diagnosis is based on guidelines performed on patients not affected by CF. The aim of this review is to provide the pathophysiology, diagnostic and therapeutic options, complications, and future directions in the management of GERD patients with CF.
Topics & Concepts
RefluxCystic fibrosisMedicineDiseaseGERDGastroenterologyFocus (optics)Internal medicinePhysicsOpticsGastroesophageal reflux and treatmentsDysphagia Assessment and ManagementEosinophilic Esophagitis