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Visible light-mediated radical fluoromethylation <i>via</i> halogen atom transfer activation of fluoroiodomethane

Patrick J. Deneny, Roopender Kumar, Matthew J. Gaunt

2021Chemical Science60 citationsDOIOpen Access PDF

Abstract

Generation of fluoromethyl radicals via visible light-mediated halogen atom transfer activation of fluoroiodomethane facilitates both the multicomponent synthesis of α-fluoromethyl amines and the hydrofluoromethylation of electron-deficient alkenes.

Topics & Concepts

HalogenChemistryOrganic moleculesMoleculeAtom (system on chip)PhotochemistryCombinatorial chemistryGroup (periodic table)Organic chemistryComputer scienceAlkylEmbedded systemFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds