Stannyl radical-mediated synthesis of 6<i>H</i>-1,3-oxazin-6-ones from 2-acyloxyazirines or whether free radicals can open the azirine ring?
Anastasiya V. Agafonova, Pavel А. Sakharov, Ilia A. Smetanin, Николай В. Ростовский, Alexander F. Khlebnikov, Михаил С. Новиков
Abstract
Stannyl radicals initiate a radical cascade reaction of 2-acyloxyazirines, the acyloxy group of which ensures the irreversibility of the ring cleavage and controls the switching of the reaction outcome between 1,3-oxazin-6-ones and oxazoles.
Topics & Concepts
ChemistryRadicalCascadeRing (chemistry)Cleavage (geology)AzirineStereochemistryMedicinal chemistryOrganic chemistryEngineeringFracture (geology)Geotechnical engineeringChromatographySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSynthesis and Biological Evaluation