Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment
Na Yuan, Xiaoyan Li, Meng Wang, Zhilin Zhang, Qiao Lu, Yamei Gao, Xinjian Xu, Jie Zhi, Yang Li, Zhongxin Li, Yitao Jia
Abstract
Background/Aims: This study aimed to explore the effect of gut microbiota-regulated Kupffer cells (KCs) on colorectal cancer (CRC) liver metastasis. Methods: researches were showed to demonstrate the gut microbiota and its possible mechanism in CRC liver metastasis. Results: prevented this migration. Conclusions: play key roles in CRC liver metastasis, which might be related to KC reductions in the liver.
Topics & Concepts
Proteus mirabilisBacteroidesGut floraMetastasisMedicineColistinImmunologyMicrobiologyBiologyCancerInternal medicineAntibioticsEscherichia coliBacteriaGeneBiochemistryGeneticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchMycobacterium research and diagnosis