Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity
Simon Budde, Felix Goerdeler, Johannes Floß, Peter Kreitmeier, Elliot F. Hicks, Oren Moscovitz, Peter H. Seeberger, Huw M. L. Davies, Oliver Reiser
Abstract
Hetero- and carbocyclic anellated cyclopropanes were converted in one step by a visible light induced photooxidation to their corresponding polycyclic endoperoxides, which show promising antimalarial activity.
Topics & Concepts
ChemistryRing (chemistry)Oxidative phosphorylationCombinatorial chemistryStereochemistryPhotochemistryOrganic chemistryBiochemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions