Design, synthesis of new anti-inflammatory agents with a pyrazole core: COX-1/COX-2 inhibition assays, anti-inflammatory, ulcerogenic, histopathological, molecular Modeling, and ADME studies
Khaled R.A. Abdellatif, Eman K. A. Abdelall, Heba A.H. Elshemy, Phoebe F. Lamie, El-Shaymaa El-Nahaas, Dina M. E. Amin
Topics & Concepts
ChemistryPyrazoleADMEAnti-inflammatoryStereochemistryPharmacologyBiochemistryIn vitroMedicineInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis of heterocyclic compounds