The synthesis and investigation of novel 3-benzoylbenzofurans and pyrazole derivatives for anti-HIV activity
Sinothile S. Khuzwayo, Mamoalosi A. Selepe, Debra Meyer, N.M.S.Q. Gama
Abstract
value of 5f was 31.59 ± 3.83 μM, and it displayed interactions with the active site of HIV-1 PR, suggesting competitive inhibition using molecular docking. The promising anti-HIV activities of 5f in pseudoviruses and HIV-PR motivate its further development for antiretroviral drugs.
Topics & Concepts
PyrazoleIC50ChemistryProteaseEnzymeDocking (animal)Human immunodeficiency virus (HIV)PotencyReverse transcriptaseCytotoxic T cellStereochemistryCombinatorial chemistryPharmacologyIn vitroBiochemistryVirologyBiologyMedicineRNAGeneNursingHIV/AIDS drug development and treatmentClick Chemistry and ApplicationsHIV Research and Treatment