OA03.03 Sotorasib in Combination with RMC-4630, a SHP2 Inhibitor, in KRAS p.G12C-Mutated NSCLC and Other Solid Tumors
G. Falchook, B.T. Li, K.A. Marrone, C.M. Bestvina, C.J. Langer, J.C. Krauss, J.H. Strickler, A. Meloni, Tao Dai, T. Varrieur, D.S. Hong
Topics & Concepts
KRASMedicineCancer researchReceptor tyrosine kinaseAcquired resistanceKinaseProtein-Tyrosine KinasesTyrosine-kinase inhibitorTyrosine kinasePharmacologyReceptorInternal medicineCancerBiologyGeneticsColorectal cancerProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways