Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators
Nathaniel C. Gilbert, Marcia E. Newcomer, Oliver Werz
Topics & Concepts
Arachidonate 5-lipoxygenaseLipid signalingG protein-coupled receptorChemistryLipoxygenaseDrug discoveryEnzymeLeukotrieneCell biologyAllosteric regulationBiochemistryArachidonic acidReceptorBiologyImmunologyAsthmaInflammatory mediators and NSAID effectsAsthma and respiratory diseasesEicosanoids and Hypertension Pharmacology